We produced isoprenol using a naphtha cracking-derived C4 fraction, as the main raw material. Isoprenol is used as the initiator in the synthesis of macromonomer (as known as isopentenyl polyoxyethylene ether) of polycarboxylic acid type water reducer in the construction field. It helps to realize low cement content, high water reduction rate, good reinforcing effect, great durability, and no rusting of steel for the cement mixing process. It is also in line with the modern idea of eco-friendly construction.